Endocrinology and Metabolism

Original Articles

Diabetes, Obesity and Metabolism
Sleep Duration and the Risk of Type 2 Diabetes: A Community-Based Cohort Study with a 16-Year Follow-up: Da Young Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Kyeong Jin Kim, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Seung Ku Lee, Chol Shin, Nan Hee Kim; Endocrinol Metab. 2023;38(1):146-155. Published online February 6, 2023; DOI: https://doi.org/10.3803/EnM.2022.1582

2,625 View
165 Download
5 Web of Science
5 Crossref

Background
We aimed to investigate the moderating effects of obesity, age, and sex on the association between sleep duration and the development of diabetes in Asians.
Methods
We analyzed data from a cohort of the Korean Genome and Epidemiology Study conducted from 2001 to 2020. After excluding shift workers and those with diabetes at baseline, 7,407 participants were stratified into three groups according to sleep duration: ≤5 hours/night, >5 to 7 hours/night (reference), and >7 hours/night. The Cox proportional hazards analyses were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident type 2 diabetes mellitus (T2DM). Subgroup analyses were performed according to obesity, age, and sex.
Results
During 16 years of follow-up, 2,024 cases of T2DM were identified. Individuals who slept ≤5 h/night had a higher risk of incident diabetes than the reference group (HR, 1.17; 95% CI, 1.02 to 1.33). The subgroup analysis observed a valid interaction with sleep duration only for obesity. A higher risk of T2DM was observed in the ≤5 hours/night group in non-obese individuals, men, and those aged <60 years, and in the >7 hours/night group in obese individuals (HRs were 1.34 [95% CI, 1.11 to 1.61], 1.22 [95% CI, 1 to 1.49], and 1.18 [95% CI, 1.01 to 1.39], respectively).
Conclusion
This study confirmed the effect of sleep deprivation on the risk of T2DM throughout the 16-year follow-up period. This impact was confined to non-obese or young individuals and men. We observed a significant interaction between sleep duration and obesity.

Citations

Citations to this article as recorded by

Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
Da Young Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Kyeong Jin Kim, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim
Diabetes & Metabolism Journal.2024; 48(1): 37. CrossRef
Role of Sleep and Sleep Disorders in Cardiometabolic Risk: a Review and Update
Shaden O. Qasrawi, Ahmed S. BaHammam
Current Sleep Medicine Reports.2024; 10(1): 34. CrossRef
Evaluating reliability in wearable devices for sleep staging
Vera Birrer, Mohamed Elgendi, Olivier Lambercy, Carlo Menon
npj Digital Medicine.2024;[Epub] CrossRef
All That Glitters Is Not Gold: The Same Sleep Time, but Different Diabetogenic Outcomes
Bohye Kim, Obin Kwon
Endocrinology and Metabolism.2023; 38(1): 78. CrossRef
The Link Between Sleeping and Type 2 Diabetes: A Systematic Review
Ali Darraj
Cureus.2023;[Epub] CrossRef

Thyroid
Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-Based Cohort Study: Hyemi Kwon, Jin-hyung Jung, Kyung-Do Han, Yong-Gyu Park, Jung-Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun-Jung Rhee, Won-Young Lee; Endocrinol Metab. 2018;33(2):260-267. Published online June 21, 2018; DOI: https://doi.org/10.3803/EnM.2018.33.2.260

6,412 View
128 Download
37 Web of Science
37 Crossref

Abstract PDF PubReader ePub

Background

The incidence of thyroid nodules has increased worldwide in recent years. Thyroid dysfunction is a potential risk factor for hypercholesterolemia, cardiovascular disease, osteoporosis, arrhythmia, and neuropsychiatric disease. This study investigated the prevalence and annual incidence of thyroid nodules, hypothyroidism, and hyperthyroidism in Koreans.

Methods

In this nationwide population-based cohort study, 51,834,660 subjects were included using the National Health Information database from 2006 to 2015, after the exclusion of subjects with thyroid cancer.

Results

The prevalence in Korea in 2015 of thyroid nodules, hypothyroidism in patients taking thyroid hormone, and hyperthyroidism in patients undergoing treatment was 15.82/1,000 population, 15.94/1,000 population, and 2.76/1,000 population, respectively. All these diseases were more prevalent among women than among men. The number of incident cases of these three thyroid diseases steadily increased from 2006 to 2012, and then decreased through 2015. The incidence of thyroid nodules, hypothyroidism treated with thyroid hormone, and treated hyperthyroidism was 6.79/1,000 population, 1.76/1,000 population, and 0.55/1,000 population, respectively, in Korea in 2015. The use of methimazole continuously increased, from 33% of total antithyroid drug prescriptions in 2006 to 74.4% in 2015, and it became the most frequently prescribed antithyroid drug in Korea. In contrast, the use of propylthiouracil continuously decreased.

Conclusion

This was the first nationwide study of the prevalence and annual incidence of thyroid nodules, hypothyroidism, and hyperthyroidism to take into account recent changes and to include the current status of patients receiving treatment.

Citations

Citations to this article as recorded by

New-onset atrial fibrillation in seropositive rheumatoid arthritis: association with disease-modifying anti-rheumatic drugs treatment
Hyung Woo Kim, Minkyung Han, Inkyung Jung, Sung Soo Ahn
Rheumatology.2024; 63(3): 630. CrossRef
Nonalcoholic Fatty Liver Disease and the Risk of Thyroid Cancer Among Young Adults in South Korea
Hyemi Kwon, Kyung-Do Han, Sun Joon Moon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1095. CrossRef
Endocrine and metabolic comorbidities in primary cicatricial alopecia: A nationwide population‐based study
Da‐Ae Yu, Seong Rae Kim, Soo Ick Cho, Ohsang Kwon
The Journal of Dermatology.2024; 51(3): 429. CrossRef
Risk of non-thyroidal autoimmune diseases in patients with Graves’ disease: a nationwide retrospective cohort study
Seo Young Sohn, Jiyeon Ahn, Min Kyung Lee, Jae Hyuk Lee, Ji-Won Kwon, Ji-Min Kweon, Ju-Yeun Lee
Rheumatology.2024;[Epub] CrossRef
Cancer Risk in Graves Disease with Radioactive131I Treatment: A Nationwide Cohort Study
Kyeong Jin Kim, Jimi Choi, Kyoung Jin Kim, Eyun Song, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim
Journal of Nuclear Medicine.2024; : jnumed.123.266531. CrossRef
Long-term effect of thyrotropin-binding inhibitor immunoglobulin on atrial fibrillation in euthyroid patients
Jung-Chi Hsu, Kang-Chih Fan, Ting-Chuan Wang, Shu-Lin Chuang, Ying-Ting Chao, Ting-Tse Lin, Kuan-Chih Huang, Lian-Yu Lin, Lung-Chun Lin
Endocrine Practice.2024;[Epub] CrossRef
Myotonic dystrophy type 1 in South Korea: a comprehensive analysis of cancer and comorbidity risks
Incheol Seo, Jin-Mo Park
Neurological Sciences.2024;[Epub] CrossRef
Association of ITM2A rs1751094 polymorphism on X chromosome in Korean pediatric patients with autoimmune thyroid disease
Won K. Cho, In‐Cheol Baek, Sung E. Kim, Mirae Kim, Tai‐Gyu Kim, Byung‐Kyu Suh
Immunity, Inflammation and Disease.2023;[Epub] CrossRef
Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
Meejeong Kim, Sora Jeon, Chan Kwon Jung
Endocrine Pathology.2023; 34(2): 247. CrossRef
Cancer and Mortality Risks of Graves’ Disease in South Korea Based on National Data from 2010 to 2019
Young Ju Choi, Kyungdo Han, Won Kyoung Cho, Min Ho Jung, Byung-Kyu Suh
Clinical Epidemiology.2023; Volume 15: 535. CrossRef
Acromegaly and the long-term fracture risk of the vertebra and hip: a national cohort study
Hyemi Kwon, Kyung-Do Han, Bong-Sung Kim, Sun Joon Moon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Osteoporosis International.2023; 34(9): 1591. CrossRef
Association of Thyroid Hormone Medication Adherence With Risk of Dementia
Saemi Han, Seogsong Jeong, Seulggie Choi, Sun Jae Park, Kyae Hyung Kim, Gyeongsil Lee, Yoosun Cho, Joung Sik Son, Sang Min Park
The Journal of Clinical Endocrinology & Metabolism.2023; 109(1): e225. CrossRef
Increased risk of incident gout in patients with hyperthyroidism: a nationwide retrospective cohort study
Ju-Yeun Lee, So-Yeon Park, Seo Young Sohn
Rheumatology International.2023; 44(3): 451. CrossRef
The Current Status of Hyperthyroidism in Korea
Hyemi Kwon
Endocrinology and Metabolism.2023; 38(4): 392. CrossRef
Prevalence, Treatment Status, and Comorbidities of Hyperthyroidism in Korea from 2003 to 2018: A Nationwide Population Study
Hwa Young Ahn, Sun Wook Cho, Mi Young Lee, Young Joo Park, Bon Seok Koo, Hang-Seok Chang, Ka Hee Yi
Endocrinology and Metabolism.2023; 38(4): 436. CrossRef
Comprehensive analysis of chemokine gene polymorphisms in Korean children with autoimmune thyroid disease
Chungwoo Shin, In-Cheol Baek, Won Kyoung Cho, Tai-Gyu Kim, Byung-Kyu Suh
Scientific Reports.2023;[Epub] CrossRef
Analysis of the status of treatment of benign thyroid diseases — a public health problem aggravated in the COVID-19 pandemic era
Giulianno Molina Melo, Antonio José Gonçalves, Fernando Walder, Carolina Ferraz, Murilo Catafesta Neves, Marcio Abrahão, Onivaldo Cervantes
Brazilian Journal of Otorhinolaryngology.2022; 88(6): 982. CrossRef
Graves’ disease and the risk of Parkinson’s disease: a Korean population-based study
Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Jinyoung Youn, Ji Oh Mok, Chul-Hee Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
Brain Communications.2022;[Epub] CrossRef
Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study
Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Hye Ryoun Jang, Bo-Yeon Kim, Chan-Hee Jung, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
Endocrinology and Metabolism.2022; 37(2): 281. CrossRef
Incidence of hypothyroidism after treatment for breast cancer: A Korean population-based study
Jongmoo Park, Choongrak Kim, Yongkan Ki, Wontaek Kim, Jiho Nam, Donghyun Kim, Dahl Park, Hosang Jeon, Dong Woon Kim, Ji Hyeon Joo, Claudio Andaloro
PLOS ONE.2022; 17(6): e0269893. CrossRef
Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan
Ting-Yuan Liu, Wen-Ling Liao, Tzu-Yuan Wang, Chia-Jung Chan, Jan-Gowth Chang, Yu-Chia Chen, Hsing-Fang Lu, Hsien-Hui Yang, Shih-Yin Chen, Fuu-Jen Tsai
Frontiers in Medicine.2022;[Epub] CrossRef
Graves’ disease, its treatments, and the risk of atrial fibrillation: A Korean population-based study
Yoon Young Cho, Bongseong Kim, Dughyun Choi, Chul-Hee Kim, Dong Wook Shin, Jee Soo Kim, Seung-Jung Park, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
Frontiers in Endocrinology.2022;[Epub] CrossRef
Risk of autoimmune diseases in recurrent aphthous ulcer patients: A nationwide population study
Young Chan Lee, Su Jin Jeong, Young‐Gyu Eun, Ran Song, In‐Hwan Oh
Oral Diseases.2021; 27(6): 1443. CrossRef
Hyperthyroidism Prevalence in China After Universal Salt Iodization
Chuyuan Wang, Yongze Li, Di Teng, Xiaoguang Shi, Jianming Ba, Bing Chen, Jianling Du, Lanjie He, Xiaoyang Lai, Yanbo Li, Haiyi Chi, Eryuan Liao, Chao Liu, Libin Liu, Guijun Qin, Yingfen Qin, Huibiao Quan, Bingyin Shi, Hui Sun, Xulei Tang, Nanwei Tong, Gui
Frontiers in Endocrinology.2021;[Epub] CrossRef
Comorbidity network analysis related to obesity in middle-aged and older adults: findings from Korean population-based survey data
Hye Ah Lee, Hyesook Park
Epidemiology and Health.2021; 43: e2021018. CrossRef
Prevalence of Hyperthyroidism and Hypothyroidism and its Correlation with Serum Antithyroglobulin among patients in Kirkuk-Iraq ‎
Sabah Mohammed Salih, Wijdan Abdullameer Kamel, Mohammed Talat Abbas, Kasim Sakran Abass
Journal Of Advanced Pharmacy Education And Research.2021; 11(2): 57. CrossRef
A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
Ka-Won Kang, Ji Eun Song, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
Scientific Reports.2021;[Epub] CrossRef
Incidence and Mortality of Myocardial Infarction and Stroke in Patients with Hyperthyroidism: A Nationwide Cohort Study in Korea
Hyun Jung Kim, Taeuk Kang, Min Ji Kang, Hyeong Sik Ahn, Seo Young Sohn
Thyroid.2020; 30(7): 955. CrossRef
Vitamin D supplementation does not prevent the recurrence of Graves’ disease
Yoon Young Cho, Yun Jae Chung
Scientific Reports.2020;[Epub] CrossRef
Binding and Activity of Tetrabromobisphenol A Mono-Ether Structural Analogs to Thyroid Hormone Transport Proteins and Receptors
Xiao-Min Ren, Linlin Yao, Qiao Xue, Jianbo Shi, Qinghua Zhang, Pu Wang, Jianjie Fu, Aiqian Zhang, Guangbo Qu, Guibin Jiang
Environmental Health Perspectives.2020;[Epub] CrossRef
Epidemiology of metabolic syndrome and its components in Chinese patients with a range of thyroid-stimulating hormone concentrations
Kun Tang, Qiao Zhang, Nian-chun Peng, Miao Zhang, Shu-jing Xu, Hong Li, Ying Hu, Chun-ju Xue, Li-xin Shi
Journal of International Medical Research.2020; 48(11): 030006052096687. CrossRef
The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies
Seo Young Sohn, Eunyoung Lee, Min Kyung Lee, Jae Hyuk Lee
Endocrinology and Metabolism.2020; 35(4): 786. CrossRef
Prevalence of Thyroid Disease in Patients Surgically Treated for Pituitary Disease
Kim, Cho, Ku, Jung, Moon, Kim, Shin, Kim, Lee
Journal of Clinical Medicine.2019; 8(8): 1142. CrossRef
Association of Thyroid-Stimulating Hormone and Thyroid Hormones with Cardiometabolic Risk Factors in Euthyroid Children and Adolescents Aged 10–18 Years: A Population-Based Study
Cheol Gyu Ma, Young Suk Shim
Scientific Reports.2019;[Epub] CrossRef
Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
Scientific Reports.2019;[Epub] CrossRef
Evaluation of the relationship of subclinical hypothyroidism with metabolic syndrome and its components in adolescents: a population-based study
Min-Kyung Lee, Yoo Mee Kim, Seo-Young Sohn, Jae-Hyuk Lee, Young Jun Won, Se Hwa Kim
Endocrine.2019; 65(3): 608. CrossRef
Autoimmune thyroiditis and central serous chorioretinopathy may have a relation
Brijesh Takkar, Harsha Saxena, Anubha Rathi, Rekha Singh
Medical Hypotheses.2018; 121: 180. CrossRef

Clinical Study
Changes in Body Composition According to Age and Sex among Young Non-Diabetic Korean Adults: The Kangbuk Samsung Health Study: Seul-Ki Kim, Yu-Hyun Kwon, Jung Hwan Cho, Da Young Lee, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee; Endocrinol Metab. 2017;32(4):442-450. Published online November 21, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.4.442

6,185 View
63 Download
18 Web of Science
20 Crossref

Abstract PDF PubReader

Background

Age-related decreases in lean mass represent a serious health problem. We aimed to analyze the risks of rapid decreases in lean mass by age and sex in relatively young Korean adults during a 4-year follow-up study.

Methods

A total of 65,856 non-diabetic participants (59.5% men, mean age 39.1 years) in a health screening program were subjected to bioimpedance body composition analyses and metabolic parameter analyses at baseline and after 4 years. The participants were sub-divided according to age, and additionally to six groups by age and the degree of body weight change over the 4-year period. The actual changes in body weight, lean mass, and fat mass and the percent changes over the 4-year period were assessed.

Results

The percent change in lean mass decreased and the percent change of fat mass increased with increasing age in every age and sex group. However, the annual percent decrease in lean mass and percent increase in fat mass were significantly higher among women than among men (−0.26% vs. −0.15% and 0.34% vs. 0.42%, respectively; P<0.01). Participants who were older than 50 years and had a weight loss <−5% during the 4 years had significantly greater decreases in lean mass and smaller decreases in fat mass, compared to those who were younger than 50 years. An odds ratio analysis to determine the lowest quartile of the percent change in lean mass according to age group revealed that participants older than 60 years had a significantly increased risk of a rapid decrease in the lean mass percentage (2.081; 95% confidence interval, 1.678 to 2.581).

Conclusion

Even in this relatively young study population, the lean mass decreased significantly with age, and the risk of a rapid decrease in lean mass was higher among women than among men. Furthermore, the elderly exhibited a significantly more rapid decrease in lean mass, compared with younger participants.

Citations

Citations to this article as recorded by

Obesity, Physical Performance, Balance Confidence, and Falls in Community-Dwelling Older Adults: Results from the Korean Frailty and Aging Cohort Study
Ga Yang Shim, Myung Chul Yoo, Yunsoo Soh, Jinmann Chon, Chang Won Won
Nutrients.2024; 16(5): 614. CrossRef
Multisystem physiological perspective of human frailty and its modulation by physical activity
Joseph A. Taylor, Paul L. Greenhaff, David B. Bartlett, Thomas A. Jackson, Niharika A. Duggal, Janet M. Lord
Physiological Reviews.2023; 103(2): 1137. CrossRef
Partial weight reduction protocols in cats lead to better weight outcomes, compared with complete protocols, in cats with obesity
Alexander J. German, Georgiana R. T. Woods-Lee, Vincent Biourge, John Flanagan
Frontiers in Veterinary Science.2023;[Epub] CrossRef
Multifaceted effects of obesity on cancer immunotherapies: Bridging preclinical models and clinical data
Logan V. Vick, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
Seminars in Cancer Biology.2023; 95: 88. CrossRef
Age-Related Trends in Body Composition among Women Aged 20–80 Years: A Cross-Sectional Study
Nirmala Rathnayake, Hasanga Rathnayake, Sarath Lekamwasam, Aron Weller
Journal of Obesity.2022; 2022: 1. CrossRef
Increased Consumption of Unsaturated Fatty Acids Improves Body Composition in a Hypercholesterolemic Chinese Population
Sumanto Haldar, Shalini Ponnalagu, Farhana Osman, Shia Lyn Tay, Long Hui Wong, Yuan Rong Jiang, Melvin Khee Shing Leow, Christiani Jeyakumar Henry
Frontiers in Nutrition.2022;[Epub] CrossRef
Development and Evaluation of a Low-cost Dairy Food Supplement with Mauritia Flexuosa (Buriti) to Combat Malnutrition: Translational Study in Mice and Institutionalized Elderly Woman
Audrey Handyara Bicalho, Fabio Ribeiro Santos, Daniele Cristina Moreira, Victor Hugo Dantas Guimarães, Guilherme Henrique Ribeiro, Alfredo Mauricio Batista De Paula, André Luis Sena Guimarães, Ulisses A. Pereira, Theles Costa, Caroline Liboreiro Paiva, Ma
Current Aging Science.2022; 15(1): 37. CrossRef
The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans
Haoyi Fu, Nicola L. Hawley, Jenna C. Carlson, Emily M. Russell, Alysa Pomer, Hong Cheng, Take Naseri, Muagututi‘a Sefuiva Reupena, Ranjan Deka, Courtney C. Choy, Stephen T. McGarvey, Ryan L. Minster, Daniel E. Weeks
Obesity Research & Clinical Practice.2022; 16(3): 220. CrossRef
Relationship Between Handgrip Strength and the Prevalence of Diabetes Mellitus Among Korean Adults: Korean National Health and Nutrition Examination Survey, 2014-2018
Sung-hyun Hong, Ji-yong Byeon, Ji-hee Min, Dong-hyuk Park, Won-hee Cho, Justin Y. Jeon
Exercise Science.2021; 30(1): 110. CrossRef
Cutoff points of adiposity anthropometric indices for low muscle mass screening in middle-aged and older healthy women
Rafaela Andrade do Nascimento, Mariana Carmem Apolinário Vieira, Rafaella Silva dos Santos Aguiar Gonçalves, Mayle Andrade Moreira, Maria Socorro Medeiros de Morais, Saionara Maria Aires da Câmara, Álvaro Campos Cavalcanti Maciel
BMC Musculoskeletal Disorders.2021;[Epub] CrossRef
Edema-like symptoms are common in ultra-distance cyclists and driven by overdrinking, use of analgesics and female sex – a study of 919 athletes
Philipp Gauckler, Jana S. Kesenheimer, Andreas Kronbichler, Fiona R. Kolbinger
Journal of the International Society of Sports Nutrition.2021;[Epub] CrossRef
Prevalence of low muscle mass and associated factors in community-dwelling older adults in Singapore
Siew Ling Tey, Dieu Thi Thu Huynh, Yatin Berde, Geraldine Baggs, Choon How How, Yen Ling Low, Magdalin Cheong, Wai Leng Chow, Ngiap Chuan Tan, Samuel Teong Huang Chew
Scientific Reports.2021;[Epub] CrossRef
Effects of low skeletal muscle mass and sarcopenic obesity on albuminuria: a 7-year longitudinal study
Jee Hee Yoo, Gyuri Kim, Sung Woon Park, Min Sun Choi, Jiyeon Ahn, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee, Mira Kang, Jae Hyeon Kim
Scientific Reports.2020;[Epub] CrossRef
Age group and gender-wise comparison of obesity indices in subjects of Varanasi
Kumar Sarvottam, Prabhat Ranjan, Umashree Yadav
Indian Journal of Physiology and Pharmacology.2020; 64: 109. CrossRef
DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma
Ayoung Jeong, Medea Imboden, Akram Ghantous, Alexei Novoloaca, Anne-Elie Carsin, Manolis Kogevinas, Christian Schindler, Gianfranco Lovison, Zdenko Herceg, Cyrille Cuenin, Roel Vermeulen, Deborah Jarvis, André Amaral, Florian Kronenberg, Paolo Vineis, Nic
International Journal of Environmental Research and Public Health.2019; 16(4): 600. CrossRef
Body shape, fear of falling, physical performance, and falls among individuals aged 55 years and above
Sheng Hui Kioh, Sumaiyah Mat, Shahrul B. Kamaruzzaman, Fatimah Ibrahim, Mas Sahidayana Mokhtar, Noran N. Hairi, Robert G. Cumming, Phyo Kyaw Myint, Maw Pin Tan
European Geriatric Medicine.2019; 10(5): 801. CrossRef
Low lean tissue mass can be a predictor of one-year survival in hemodialysis patients
Aleksandra Rymarz, Julia Gibińska, Maria Zajbt, Wiesław Piechota, Stanisław Niemczyk
Renal Failure.2018; 40(1): 231. CrossRef
Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study
Gyuri Kim, Seung‐Eun Lee, You‐Bin Lee, Ji Eun Jun, Jiyeon Ahn, Ji Cheol Bae, Sang‐Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon‐Kyu Lee, Jae Hyeon Kim
Hepatology.2018; 68(5): 1755. CrossRef
Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population‐based study
Eun‐Jung Rhee, Jung‐Hwan Cho, Hyemi Kwon, Se‐Eun Park, Jin‐Hyung Jung, Kyung‐Do Han, Yong‐Gyu Park, Hye Soon Park, Yang‐Hyun Kim, Soon‐Jib Yoo, Won‐Young Lee
The Journal of Clinical Hypertension.2018; 20(10): 1417. CrossRef
Decreasing Lean Body Mass with Age: Challenges and Opportunities for Novel Therapies
Chrysoula Boutari, Christos S. Mantzoros
Endocrinology and Metabolism.2017; 32(4): 422. CrossRef

Clinical Study
Waist Circumference as a Marker of Obesity Is More Predictive of Coronary Artery Calcification than Body Mass Index in Apparently Healthy Korean Adults: The Kangbuk Samsung Health Study: Jongsin Park, Eun Seo Lee, Da Young Lee, Jihyun Kim, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee; Endocrinol Metab. 2016;31(4):559-566. Published online December 20, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.4.559

4,560 View
38 Download
33 Web of Science
30 Crossref

Abstract PDF PubReader

Background

We aimed to assess the risk for coronary artery calcification (CAC) according to groups subdivided by body mass index (BMI) and waist circumference (WC) in apparently healthy Korean adults.

Methods

Thirty-three thousand four hundred and thirty-two participants (mean age, 42 years) in a health screening program were divided into three groups according to BMI: <23 kg/m² (normal), 23 to 25 kg/m² (overweight), and >25 kg/m² (obese). In addition, the participants were divided into two groups according to WC. Coronary artery calcium score (CACS) was measured with multi-detector computed tomography in all participants. Presence of CAC was defined as CACS >0.

Results

When logistic regression analysis was performed with the presence of CAC as the dependent variable, the risk for CAC increased as BMI increased after adjusting for confounding variables (1.102 [95% confidence interval (CI), 1.000 to 1.216]; 1.284 [95% CI, 1.169 to 1.410]; in the overweight and obese groups vs. the normal weight group). When the participants were divided into six groups according to BMI and WC, the subjects with BMI and WC in the obese range showed the highest risk for CAC (1.321 [95% CI, 1.194 to 1.461]) and those with BMI in the overweight range and WC in the obese range showed the second highest risk for CAC (1.235 [95% CI, 1.194 to 1.461]).

Conclusion

Participants with obesity defined by both BMI and WC showed the highest risk for CAC. Those with BMIs in the overweight range but with WC in the obese range showed the second highest risk for CAC, suggesting that WC as a marker of obesity is more predictive of CAC than BMI.

Citations

Citations to this article as recorded by

Relationship Between Blood Group and  Obesity Reduction Through Diet Among  Adults of Urban Bihar
Vidya, Rahul Singh
Journal of Health Management.2024;[Epub] CrossRef
Association of Coronary Artery Calcium Density and Volume With Predicted Atherosclerotic Cardiovascular Disease Risk and Cardiometabolic Risk Factors in South Asians: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study
Mahmoud Al Rifai, Alka M. Kanaya, Namratha R Kandula, Jaideep Patel, Mouaz H. Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H. Criqui, Salim S. Virani
Current Problems in Cardiology.2023; 48(4): 101105. CrossRef
Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
Göran Bergström, Annika Rosengren, Elin Bacsovics Brolin, John Brandberg, Kerstin Cederlund, Gunnar Engström, Jan E. Engvall, Maria J. Eriksson, Isabel Gonçalves, Emil Hagström, Stefan K. James, Tomas Jernberg, Mikael Lilja, Martin Magnusson, Anders Perss
Atherosclerosis.2023; 373: 46. CrossRef
Weight gain with age and coronary atherosclerosis: Only the tip of a deadly iceberg
Isabelle Lemieux, Jean-Pierre Després
Atherosclerosis.2023; 373: 55. CrossRef
Central obesity and its associated factors among cancer patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Meseret Derbew Molla, Haileab Fekadu Wolde, Ephrem Tafesse Teferi, Anteneh Ayelign Kibret
Frontiers in Oncology.2023;[Epub] CrossRef
Added value of waist circumference to body mass index for predicting fracture risk in obesity: a prospective study from the CARTaGENE cohort
Anne-Frédérique Turcotte, Sonia Jean, Suzanne N. Morin, Fabrice Mac-Way, Claudia Gagnon
Archives of Osteoporosis.2023;[Epub] CrossRef
Prevalence and significance of risk enhancing biomarkers in the United States population at intermediate risk for atherosclerotic disease
Gloria L. Vega, Jijia Wang, Scott M. Grundy
Journal of Clinical Lipidology.2022; 16(1): 66. CrossRef
Pericardial fat, thoracic peri-aortic adipose tissue, and systemic inflammatory marker in nonalcoholic fatty liver and abdominal obesity phenotype
Chun-Ho Yun, Jing-Rong Jhuang, Meng-Ting Tsou
Scientific Reports.2022;[Epub] CrossRef
Central Obesity and Associated Factors Among Urban Adults in Dire Dawa Administrative City, Eastern Ethiopia
Ephrem Israel, Kalkidan Hassen, Melese Markos, Kiber Wolde, Behailu Hawulte
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 601. CrossRef
Gender-Based Association of Coronary Artery Calcification and Framingham Risk Score With Non-alcoholic Fatty Liver Disease and Abdominal Obesity in Taiwanese Adults, a Cross-Sectional Study
Meng-Ting Tsou, Jau-Yuan Chen
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Joint Associations of Obesity and Cardiorespiratory Fitness With Coronary Artery Calcium Composition
Sae Young Jae, Hyun Jeong Kim, Kyung Hyun Lee, Setor K. Kunutsor, Kevin S. Heffernan, Yoon-Ho Choi, Mira Kang
Journal of Cardiopulmonary Rehabilitation and Prevention.2022; 42(3): 202. CrossRef
Proposing new body mass index and waist circumference cut-offs based on cardiometabolic risks for a Central Asia population: A feasibility study
Aknur Kali, Arnur Gusmanov, Marat Aripov, Mei-Yen Chan
Frontiers in Endocrinology.2022;[Epub] CrossRef
New Model for Predicting the Presence of Coronary Artery Calcification
Samel Park, Min Hong, HwaMin Lee, Nam-jun Cho, Eun-Young Lee, Won-Young Lee, Eun-Jung Rhee, Hyo-Wook Gil
Journal of Clinical Medicine.2021; 10(3): 457. CrossRef
Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Tiffany M. Powell-Wiley, Paul Poirier, Lora E. Burke, Jean-Pierre Després, Penny Gordon-Larsen, Carl J. Lavie, Scott A. Lear, Chiadi E. Ndumele, Ian J. Neeland, Prashanthan Sanders, Marie-Pierre St-Onge
Circulation.2021;[Epub] CrossRef
Association Between Obesity and Blood Pressure in Common Korean People
Nam Lyong Kang
Vascular Health and Risk Management.2021; Volume 17: 371. CrossRef
Prevalence of abdominal obesity and its association with cardiovascular risk among the adult population in Burkina Faso: findings from a nationwide cross-sectional study
Kadari Cisse, Sékou Samadoulougou, Mady Ouedraogo, Seni Kouanda, Fati Kirakoya-Samadoulougou
BMJ Open.2021; 11(7): e049496. CrossRef
Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis
Anne-Frédérique Turcotte, Sarah O’Connor, Suzanne N. Morin, Jenna C. Gibbs, Bettina M. Willie, Sonia Jean, Claudia Gagnon, Tuan Van Nguyen
PLOS ONE.2021; 16(6): e0252487. CrossRef
Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Sue K. Park, Yong-Soo Kim, Yeong Hoon Kim, Kyu Hun Choi, Kook-Hwan Oh, Seong Kwon Ma, Soo Wan Kim
Nutrients.2021; 13(10): 3381. CrossRef
Associations among Obesity Degree, Glycemic Status, and Risk of Heart Failure in 9,720,220 Korean Adults
Eun-Jung Rhee, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Won-Young Lee
Diabetes & Metabolism Journal.2020; 44(4): 592. CrossRef
The effects of supplementation with L-arginine on anthropometric indices and body composition in overweight or obese subjects: A systematic review and meta-analysis
Mohammad Zeinali Khosroshahi, Omid Asbaghi, Sajjad Moradi, Mahnaz Rezaei kelishadi, Mojtaba Kaviani, Mahnaz Mardani, Cyrus Jalili
Journal of Functional Foods.2020; 71: 104022. CrossRef
Effect of Exercises and Diet Intervention in Pregnancy on Postpartum Weight Retention and Obesity Markers: Findings in Indian Women
Alka Pawalia, Sivachidambaram Kulandaivelan, Vikram Singh Yadav
Journal of Women's Health Physical Therapy.2020; 44(3): 123. CrossRef
Magnitude of Central Obesity and its Associated Factors Among Adults in Urban Areas of Northwest Ethiopia

Meseret Derbew Molla, Haileab Fekadu Wolde, Asmamaw Atnafu
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 4169. CrossRef
Is the coronary artery calcium score the first-line tool for investigating patients with severe hypercholesterolemia?
Sandra Kutkienė, Žaneta Petrulionienė, Aleksandras Laucevičius, Rimantė Čerkauskienė, Vytautas Kasiulevičius, Artūras Samuilis, Virginija Augaitienė, Aurelija Gedminaitė, Gintarė Bieliauskienė, Akvilė Šaulytė-Mikulskienė, Justina Staigytė, Emilija Petruli
Lipids in Health and Disease.2019;[Epub] CrossRef
Letter: Association of Z-Score of the Log-Transformed A Body Shape Index with Cardiovascular Disease in People Who Are Obese but Metabolically Healthy: The Korea National Health and Nutrition Examination Survey 2007-2010 (J Obes Metab Syndr 2018;27:158-65
Eun-Jung Rhee
Journal of Obesity & Metabolic Syndrome.2019; 28(2): 139. CrossRef
Lower Leg Fat Depots Are Associated with Albuminuria Independently of Obesity, Insulin Resistance, and Metabolic Syndrome (Korea National Health and Nutrition Examination Surveys 2008 to 2011)
Eugene Han, Nan Hee Cho, Mi Kyung Kim, Hye Soon Kim
Diabetes & Metabolism Journal.2019; 43(4): 461. CrossRef
Abdominal obesity increases metabolic risk factors in non-obese adults: a Hungarian cross-sectional study
Anita Lukács, Edina Horváth, Zsuzsanna Máté, Andrea Szabó, Katalin Virág, Magor Papp, János Sándor, Róza Ádány, Edit Paulik
BMC Public Health.2019;[Epub] CrossRef
Association between thyroid hormone levels, body composition and insulin resistance in euthyroid subjects with normal thyroid ultrasound: The Kangbuk Samsung Health Study
Hyemi Kwon, Jung‐Hwan Cho, Da Young Lee, Se Eun Park, Cheol‐Young Park, Won‐Young Lee, Ki‐Won Oh, Sung‐Woo Park, Eun‐Jung Rhee
Clinical Endocrinology.2018; 89(5): 649. CrossRef
Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
Eun-Jung Rhee
Diabetes & Metabolism Journal.2018; 42(1): 19. CrossRef
Effects of lobeglitazone, a novel thiazolidinedione, on adipose tissue remodeling and brown and beige adipose tissue development in db/db mice
G Kim, Y-h Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
International Journal of Obesity.2018; 42(3): 542. CrossRef
Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef

First
Prev
Page of 1
Next
Last

Search